Protein Details: Two pore calcium channel protein 1

Protein ID

ICDB_Pro_0995

Protein Name

Two pore calcium channel protein 1

Gene Name

TPC1; Os01g0678500; LOC_Os01g48680; B1144G04.26-1; OsJ_03004

Organism

Oryza sativa subsp. japonica (Rice)

Length

757 amino acids

AlphaFoldDB

AF-Q5QM84-F1-model_v4.pdb

Function

May function as one of the major voltage-gated Ca(2+) channel (VDCC) across the plasma membrane. May be involved in the regulation of cytosolic Ca(2+) and in growth and development. Acts as the major ROS-responsive Ca(2+) channel and is the possible target of Al-dependent inhibition. Determines sensitivity to T.viride xylanase elicitor. Plays a regulatory role in elicitor-induced defense responses and hypersensitive cell death.

Sequence

MRERGEMREAKAPLIAEAAEHISHSHGSGSSGTGSHTSGGGGGWRGSRQYQRRSDALAYGNRYQKAAALVDLAEDGVGIPEDVLNDTRFERAMRFYFVYLRLDWLWSLNLFALILLNFLEKPLWCRGYSQHACDQRDLYFLGQLPYLSKTESLIYEGLTLVILVMDIFYPLSYEGLNLFWKNTINKLKVLLLFILACDILVFAFSPQPFRVAPYIRVAFLIMNIRELRMCAVTLVGMVGTYLNVLALSLLFLLFASWLAYVTFEDTPQGKTVFSSYGTTLYQMFILFTTSNNPDVWVPAYKSSRWSSLFFIVYVLLGVYFLTNLILAVIYDSFKEQLAKQVSQADCTRKSILEKAFGIIDATGQGYLNKEQCLSLLDELNKYRSLPKTSREDFELIFAELDQSGDFKVTSEEFATLCNTIAIKFQKEPPPSYLEKYPSFYHSALCEWLKSFVRSPLFEYIVIFVLLMNLVAVIIETTLDIENSSSQKVWQEVEFVFGWIYVIEMALKIFSLGFGAYWMEGQNKFDFVLTWTIFIGETLTFAFPSKLSFLSNGEWIRYLLLGRMLRLTRILLQVRRFRAFVATFFTLMSSLMPYLGIVFCTLCIYCSLGLQIFGGIVYAGNPTLEETDLFSNDYLLFNFNDYPSGMVTLFNLLVMGNWQAWMESYRQLTGSYWSLIYFVSFYLISVLLLLNLIVAFVLEAFFAEMELEKDGEADIQDPTLEGRNRRRSVRVRTKGTMVDILLHHMLSNELDGSQNRDQ

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Expressed in shoot; mature leaf; cultured cells; and at lower level in roots

DOI ID

10.1093/pcp/pch053; 10.1093/pcp/pch082; 10.1038/nature01184; 10.1038/nature03895; 10.1093/nar/gkm978; 10.1186/1939-8433-6-4; 10.1371/journal.pbio.0030038; 10.1111/j.1365-313x.2005.02415.x

RefSeq

XP_015621659.1